Development of recombinant serpin MDPK67b for treatment of chemotherapy induced neutropenia

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INNOSUISSE

Project number

10776.1;7 PFLS-LS

Project title

Development of recombinant serpin MDPK67b for treatment of chemotherapy induced neutropenia

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Short description (English)	Development of recombinant serpin MDPK67b for treatment of chemotherapy induced neutropenia
Abstract (English)	This is a development project for use of MDPK67b to diminish the effects of neutropenia provoked by treatment with chemotherapeutic agents. The effects of MDPK67b on myeloid cells will be investigated in vitro, with the aim of elucidating the mechanism of action. In vivo proof of concept studies will be performed in mice and marmoset models. At the successful completion of this project, MDPK67b is expected to be able to enter into clinical trials for this indication.

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Text

Short description
(English)

Development of recombinant serpin MDPK67b for treatment of chemotherapy induced neutropenia

Abstract
(English)

This is a development project for use of MDPK67b to diminish the effects of neutropenia provoked by treatment with chemotherapeutic agents. The effects of MDPK67b on myeloid cells will be investigated in vitro, with the aim of elucidating the mechanism of action. In vivo proof of concept studies will be performed in mice and marmoset models. At the successful completion of this project, MDPK67b is expected to be able to enter into clinical trials for this indication.