In-line multi-analyte detection for the hemofiltration system Aquarius (acute blood purification treatment system)

• Research unit: INNOSUISSE
• Project number: 10550.2;4 PFLS-LS

Short description (English)

In-line multi-analyte detection for the hemofiltration system Aquarius (acute blood purification treatment system)

Short description (French)

In-line multi-analyte detection for the hemofiltration system Aquarius (acute blood purification treatment system)

Abstract (English)

Hemofiltration is a renal replacement therapy used in the intensive care units. All along the process, ionized calcium and glucose concentrations as well as pH in blood plasma must be accurately controlled in order to reduce mortality of critically ill patients. For this purpose, we propose a novel approach which may enable a continuous and accurate measurement of these parameters. It relies on a chemico-mechanical method which aims at detecting changes in viscosity or swelling of responsive block copolymer hydrogels only sensitive to parameters of interest. The goal of this study is to prove the concept in in vitro conditions in blood plasma and to realize a real size demonstrator by means of rapid prototyping techniques such as stereolithography.

Abstract (French)

Hemofiltration is a renal replacement therapy used in the intensive care units. All along the process, ionized calcium and glucose concentrations as well as pH in blood plasma must be accurately controlled in order to reduce mortality of critically ill patients. For this purpose, we propose a novel approach which may enable a continuous and accurate measurement of these parameters. It relies on a chemico-mechanical method which aims at detecting changes in viscosity or swelling of responsive block copolymer hydrogels only sensitive to parameters of interest. The goal of this study is to prove the concept in in vitro conditions in blood plasma and to realize a real size demonstrator by means of rapid prototyping techniques such as stereolithography.