Abstract
(English)
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In contrast to state-of-the-art 2D culturing technologies, which do not reflect the characteristics and functionality of intact tissues or whole organs, we propose here a simple and cost-effective way to achieve (a) biomimetic 3D cultures and (b) co-culturing of different tissue types in a functional arrangement. The final goal is a chip/microfluidics design that mimics the organism`s physiology and the interplay of the individual tissues so that the effects of specific interventions can be tested with a higher predictability in drug development, diagnostics or personalized medicine ('The Body on a Chip').
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