EnOp - Optimization of Endothelial Cell Layer Growth and Functionality by Coronary Artery Stent Substrate Nano-Structuring and Micro-Scale Flow Control.

• Forschungsstelle: INNOSUISSE
• Projektnummer: 9921.2;7 PFLS-LS
• Projekttitel Englisch: EnOp - Optimization of Endothelial Cell Layer Growth and Functionality by Coronary Artery Stent Substrate Nano-Structuring and Micro-Scale Flow Control.

Kurzbeschreibung (Deutsch)

EnOp - Optimization of Endothelial Cell Layer Growth and Functionality by Coronary Artery Stent Substrate Nano-Structuring and Micro-Scale Flow Control.

Kurzbeschreibung (Englisch)

EnOp - Optimization of Endothelial Cell Layer Growth and Functionality by Coronary Artery Stent Substrate Nano-Structuring and Micro-Scale Flow Control.

Abstract (Deutsch)

Cardiovascular diseases are the leading cause of death in the developed world. Of these, coronary artery disease (CAD) is the most relevant. One of the preferred ways of CAD treatment is the placement of coronary artery stents. In this catheter based procedure, a cylindrical mesh-like metal structure (stent) is inserted into a partially occluded artery and expanded to reestablish blood flow. In the process, the endothelial cell (EC) layer of the artery is injured, leading to localized bleeding of the artery wall. In order to prevent thrombosis and renewed arterial blockage due to uncontrolled growth of the vessel wall tissue, the EC layer has to heal expediently. In the project at hand, we will develop a novel coronary artery stent design that increases the speed of EC layer renewal. To this end, we will generate nano scale patterns on the stent surface that function as scaffolds promoting cell growth. While we have shown earlier that nano patterns can be used to direct cell growth, this project will establish the optimal pattern structure for the use on coronary artery stents.

Abstract (Englisch)

Cardiovascular diseases are the leading cause of death in the developed world. Of these, coronary artery disease (CAD) is the most relevant. One of the preferred ways of CAD treatment is the placement of coronary artery stents. In this catheter based procedure, a cylindrical mesh-like metal structure (stent) is inserted into a partially occluded artery and expanded to reestablish blood flow. In the process, the endothelial cell (EC) layer of the artery is injured, leading to localized bleeding of the artery wall. In order to prevent thrombosis and renewed arterial blockage due to uncontrolled growth of the vessel wall tissue, the EC layer has to heal expediently. In the project at hand, we will develop a novel coronary artery stent design that increases the speed of EC layer renewal. To this end, we will generate nano scale patterns on the stent surface that function as scaffolds promoting cell growth. While we have shown earlier that nano patterns can be used to direct cell growth, this project will establish the optimal pattern structure for the use on coronary artery stents.