Novel therapeutic pathways for amyotrophic lateral sclerosis (ALS): leveraging the NOX route.

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Identifiant

Unité de recherche

INNOSUISSE

Numéro de projet

9958.1;7 PFLS-LS

Titre du projet

Novel therapeutic pathways for amyotrophic lateral sclerosis (ALS): leveraging the NOX route.

Titre du projet anglais

Novel therapeutic pathways for amyotrophic lateral sclerosis (ALS): leveraging the NOX route.

Textes relatifs à ce projet

	Allemand	Français	Italien	Anglais
Description succincte	-	-	-
Résumé des résultats (Abstract)	-	-	-

Textes saisis

Catégorie	Texte
Description succincte (Anglais)	Novel therapeutic pathways for amyotrophic lateral sclerosis (ALS): leveraging the NOX route.
Résumé des résultats (Abstract) (Anglais)	UNIGE proposes to test GKT-generated proprietary NOX inhibitors in in vitro and in vivo models of amyotrophic lateral sclerosis (ALS). ALS is an incurable orphan disease, which potentially allows rapid entry of GKT inhibitors into clinical trials. Because chronic NOX inhibition might lead to immunosuppression, such possible adverse effect of GKT inhibitors will also be evaluated. This is a scientifically challenging project requiring collaboration between GKT and the academic laboratory. The project will add value through opening the CNS field for GKT.

Catégorie

Texte

Description succincte
(Anglais)

Novel therapeutic pathways for amyotrophic lateral sclerosis (ALS): leveraging the NOX route.

Résumé des résultats (Abstract)
(Anglais)

UNIGE proposes to test GKT-generated proprietary NOX inhibitors in in vitro and in vivo models of amyotrophic lateral sclerosis (ALS). ALS is an incurable orphan disease, which potentially allows rapid entry of GKT inhibitors into clinical trials. Because chronic NOX inhibition might lead to immunosuppression, such possible adverse effect of GKT inhibitors will also be evaluated. This is a scientifically challenging project requiring collaboration between GKT and the academic laboratory. The project will add value through opening the CNS field for GKT.