Development of a high-throughput screening technology to identify ligands and ligand-induced interaction partners of G protein-coupled receptors

Schrift Standard Fett
Login

Forschungsstelle

INNOSUISSE

Projektnummer

9807.1;4 PFLS-LS

Projekttitel

Development of a high-throughput screening technology to identify ligands and ligand-induced interaction partners of G protein-coupled receptors

Projekttitel Englisch

Development of a high-throughput screening technology to identify ligands and ligand-induced interaction partners of G protein-coupled receptors

Texte zu diesem Projekt

	Deutsch	Französisch	Italienisch	Englisch
Kurzbeschreibung	-	-	-
Abstract	-	-	-

Erfasste Texte

Kategorie	Text
Kurzbeschreibung (Englisch)	Development of a high-throughput screening technology to identify ligands and ligand-induced interaction partners of G protein-coupled receptors
Abstract (Englisch)	Establishing a novel screening technology to identify ligand-receptor interactions and ligand-mediated protein interactions involving G protein-coupled receptors (GPCRs). Applications include the identification of signaling events of activated GPCRs, the characterization of dynamic protein interactions and the identification of ligands for orphan GPCRs or the identification of receptors for a given ligand of interest. Furthermore, the technology enables the identification of pharmacological dugs which interfere with the recruitment of signaling molecules to engaged GPCRs. The screening system will be commercialized as a fee-for-service operation for industrial and academic customers.

Kategorie

Text

Kurzbeschreibung
(Englisch)

Development of a high-throughput screening technology to identify ligands and ligand-induced interaction partners of G protein-coupled receptors

Abstract
(Englisch)

Establishing a novel screening technology to identify ligand-receptor interactions and ligand-mediated protein interactions involving G protein-coupled receptors (GPCRs). Applications include the identification of signaling events of activated GPCRs, the characterization of dynamic protein interactions and the identification of ligands for orphan GPCRs or the identification of receptors for a given ligand of interest. Furthermore, the technology enables the identification of pharmacological dugs which interfere with the recruitment of signaling molecules to engaged GPCRs. The screening system will be commercialized as a fee-for-service operation for industrial and academic customers.