Purification platform for next generation therapeutic proteins using the MCSGP-technology with a model-predictive controller

• Research unit: INNOSUISSE
• Project number: 9664.2;5 PFIW-IW

Short description (German)

Purification platform for next generation therapeutic proteins using the MCSGP-technology with a model-predictive controller

Short description (English)

Purification platform for next generation therapeutic proteins using the MCSGP-technology with a model-predictive controller

Abstract (German)

For the next generation of therapeutic proteins, there is no comfortable platform purification technology which will cause a big challenge to the production costs. The chromatographic MCSGP-process has the potential to reduce the overall purification costs by up to 50%. In this project, the aim is to prove the performance increase of the MCSGP-process using next generation therapeutic proteins and to develop a model-based predictive controller, so that the process operates with minimal user input.

Abstract (English)

For the next generation of therapeutic proteins, there is no comfortable platform purification technology which will cause a big challenge to the production costs. The chromatographic MCSGP-process has the potential to reduce the overall purification costs by up to 50%. In this project, the aim is to prove the performance increase of the MCSGP-process using next generation therapeutic proteins and to develop a model-based predictive controller, so that the process operates with minimal user input.