Description succincte
(Anglais)
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The development of new catalysts for asymmetric synthesis is currently one of the most active fields of chemistry. Catalytic asymmetric catalysis is a central theme in this application. It provides an efficient powerful method for organic synthesis and strongly contributes to an economically sound and sustainable development since it changes the way new products and materials are assembled. The application is divided into the following topics Project A: Bulky chiral N-heterocyclic carbene ligands and applications in Pd catalyzed asymmetric intramolecu-lar arylation of amides to give oxindoles. Project B: Helical tetradentate N,O-ligands for catalysis with early transition metals
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Partenaires et organisations internationales
(Anglais)
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AT, BE, CH, DE, DK, ES, FI, FR, GR, HU, IE, IT, LT, MT, NL, PL, PT, RO, SE, SI, SK, TR, UK
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Résumé des résultats (Abstract)
(Anglais)
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In this project the focus was on the control of new stereogenic centers in important heterocyclic compounds (e.g. oxindoles, indolines, dihydroquinolines). The novelty of our approach is that we use a one point binding chiral ligand in conjunction with a transition metal to control induction. These new N-heterocyclic ligands, which emanate from this laboratory, exert excellent control of the reaction space by adopting a chiral environment through the minimization of allylic strain. In a spectacular development we were able in 2011 to show that it is possible to implicate heterofore unreactive C-H bonds in a selective way. This was demonstrated in the synthesis of chiral indolines in an article that has found resonance in the national and international press. In another field, but using key ingredients of the ligands mentioned above, collaborative research with a Padova (I) group led by Prof. Giulia Licini, concerns catalytic oxidation reactions.
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