Short description
(English)
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This project aims to elucidate the relationship between insulin signalling, ER stress and the secretion of adipokines in adipocytes. these major questions will be addresse: 1) Which adipokines are secreted by adipocytes under ER stress? 2) Does inhibition of insulin signalling (at the level of IRS proteins) affect the secretion of adipokines and does it induce ER stress? 3) Does binding between IRS proteins and the ER stress regulator Grp78/BiP regulate the secretion of adiokines?
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Partners and International Organizations
(English)
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AT, BE, BG, CH, CY, CZ, DE, ES, FI, FR, HU, IL, IT, NL, NO, PL, RO, RS, SE, SI, SK, TR, UK
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Abstract
(English)
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Adipocytes produce and secrete a great number of hormones, chemokines and cytokines. These factors are collectively referred to as adipokines of which many affect systemic energy homeostasis. Whether adipocytes support or inhibit the proper regulation of blood glucose homeostasis must depend on balancing secretion of beneficial versus inhibitory factors. The ER constitutes the intracellular site of production of adipokines. ER stress which occurs in adipocytes during obesity is therefore likely to affect the secretion of adipokines and, as a consequence, would impact on systemic energy homeostasis. In our current project we study which consequences ER stress has for insulin signalling and metabolic function in adipocytes.
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