Short description
(English)
|
Dynamic combinatorial chemistry is a novel method with great potential for the development of synthetic receptors, materials, sensors and for the discovery of new ligands for proteins. The COST working group D31/0014/04 brings together most of the European groups with an active interest in this field. The aim is to further develop the underlying chemistry and theory and to deliver functional molecules in the form of inhibitors for proteins, enantioselective synthetic receptors, sensors for biomolecules or catalysts. The objective of our work in this context is the experimental and theoretical investigation of dynamic combinatorial libraries (DCLs) with complex network topologies.
|
Partners and International Organizations
(English)
|
AT, BE, CH, CZ, DE, DK, ES, FI, FR, GR, HR, HU, IL, IT, LT, NL, NO, PL, PT, SE, SI, UK
|
Abstract
(English)
|
Dynamic combinatorial chemistry is a novel method with great potential for the development of synthetic receptors, materials, sensors and for the discovery of new ligands for proteins. The COST working group D31/0014/04 brings together most of the European groups with an active interest in this field. During the project, we have established synthetic protocols for the synthesis hexanuclear coordination cages of rhodium and iridium. The cages act as exoreceptors for the large alkali metals K+ and Cs+ but show low affinity for Na+. Crystallographic and NMR spectroscopic analyses indicate that two metal ions can be coordinated to the surface of the cages. Furthermore, we have managed to build nano-sized macrocycles and cages based on ruthenium complexes. The dynamic combinatorial chemistry of the ruthenium cages was investigated and it was found that structures are strongly dependent on the solvents that were employed.
|
