Versatile nanofluidic system for single cell drug tests and local patch clamping

• Unité de recherche: INNOSUISSE
• Numéro de projet: 9191.1;5 PFNM-NM
• Titre du projet anglais: Versatile nanofluidic system for single cell drug tests and local patch clamping

Description succincte (Anglais)

Versatile nanofluidic system for single cell drug tests and local patch clamping

Résumé des résultats (Abstract) (Anglais)

Manipulating cell membranes is a tedious procedure that requires skilled personnel. We are developing a new system towards a standardized procedure for drug screening. At the heart of this instrument is an AFM (Atomic Force Microscope) cantilever with incorporated nanofluidics that can be brought in a controlled and gentle way into close contact with a living-cell membrane avoiding any cell damage. Thus multiple single-cell-measurements and handling including microinjection, sampling, local patch clamping and/or electrophysiology measurements can be performed in an automated way.