Versatile nanofluidic system for single cell drug tests and local patch clamping

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INNOSUISSE

Project number

9191.1;5 PFNM-NM

Project title

Versatile nanofluidic system for single cell drug tests and local patch clamping

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Short description (English)	Versatile nanofluidic system for single cell drug tests and local patch clamping
Abstract (English)	Manipulating cell membranes is a tedious procedure that requires skilled personnel. We are developing a new system towards a standardized procedure for drug screening. At the heart of this instrument is an AFM (Atomic Force Microscope) cantilever with incorporated nanofluidics that can be brought in a controlled and gentle way into close contact with a living-cell membrane avoiding any cell damage. Thus multiple single-cell-measurements and handling including microinjection, sampling, local patch clamping and/or electrophysiology measurements can be performed in an automated way.

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Short description
(English)

Versatile nanofluidic system for single cell drug tests and local patch clamping

Abstract
(English)

Manipulating cell membranes is a tedious procedure that requires skilled personnel. We are developing a new system towards a standardized procedure for drug screening. At the heart of this instrument is an AFM (Atomic Force Microscope) cantilever with incorporated nanofluidics that can be brought in a controlled and gentle way into close contact with a living-cell membrane avoiding any cell damage. Thus multiple single-cell-measurements and handling including microinjection, sampling, local patch clamping and/or electrophysiology measurements can be performed in an automated way.