Versatile nanofluidic system for single cell drug tests and local patch clamping

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Projektnummer

9191.1;5 PFNM-NM

Projekttitel

Versatile nanofluidic system for single cell drug tests and local patch clamping

Projekttitel Englisch

Versatile nanofluidic system for single cell drug tests and local patch clamping

Texte zu diesem Projekt

	Deutsch	Französisch	Italienisch	Englisch
Kurzbeschreibung	-	-	-
Abstract	-	-	-

Erfasste Texte

Kategorie	Text
Kurzbeschreibung (Englisch)	Versatile nanofluidic system for single cell drug tests and local patch clamping
Abstract (Englisch)	Manipulating cell membranes is a tedious procedure that requires skilled personnel. We are developing a new system towards a standardized procedure for drug screening. At the heart of this instrument is an AFM (Atomic Force Microscope) cantilever with incorporated nanofluidics that can be brought in a controlled and gentle way into close contact with a living-cell membrane avoiding any cell damage. Thus multiple single-cell-measurements and handling including microinjection, sampling, local patch clamping and/or electrophysiology measurements can be performed in an automated way.

Kategorie

Text

Kurzbeschreibung
(Englisch)

Versatile nanofluidic system for single cell drug tests and local patch clamping

Abstract
(Englisch)

Manipulating cell membranes is a tedious procedure that requires skilled personnel. We are developing a new system towards a standardized procedure for drug screening. At the heart of this instrument is an AFM (Atomic Force Microscope) cantilever with incorporated nanofluidics that can be brought in a controlled and gentle way into close contact with a living-cell membrane avoiding any cell damage. Thus multiple single-cell-measurements and handling including microinjection, sampling, local patch clamping and/or electrophysiology measurements can be performed in an automated way.