Design and development of disposable orbital shake bioreactors for pilot- and production-scale operations (up to 1'000 L) in the context of therapeutic protein production

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Research unit

INNOSUISSE

Project number

9154.1;4 PFLS-LS

Project title

Design and development of disposable orbital shake bioreactors for pilot- and production-scale operations (up to 1'000 L) in the context of therapeutic protein production

Texts for this project

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Short description (English)	Design and development of disposable orbital shake bioreactors for pilot- and production-scale operations (up to 1'000 L) in the context of therapeutic protein production
Abstract (English)	The project consists in developing orbital shake bioreactors using single-use cell culture bags for working volumes up to 1'000 L. Fluid dynamics, oxygen transfer and power input will be mainly investigated together with more practical engineering aspects for the design and construction of pilot- and production-scale prototypes. As a result, the technology is expected to be clearly more flexible and cost-effective than standard equipment used in industrial bioprocessing, which should create excellent market opportunities.

Category

Text

Short description
(English)

Design and development of disposable orbital shake bioreactors for pilot- and production-scale operations (up to 1'000 L) in the context of therapeutic protein production

Abstract
(English)

The project consists in developing orbital shake bioreactors using single-use cell culture bags for working volumes up to 1'000 L. Fluid dynamics, oxygen transfer and power input will be mainly investigated together with more practical engineering aspects for the design and construction of pilot- and production-scale prototypes. As a result, the technology is expected to be clearly more flexible and cost-effective than standard equipment used in industrial bioprocessing, which should create excellent market opportunities.