SMART BIOMATERIAL Bioactive synthetic bone repair material for large oral bone defects

• Research unit: INNOSUISSE
• Project number: 9201.1;5 PFLS-LS

Short description (German)

SMART BIOMATERIAL Bioactive synthetic bone repair material for large oral bone defects

Short description (English)

SMART BIOMATERIAL Bioactive synthetic bone repair material for large oral bone defects

Abstract (German)

In oral surgery, the treatment of large bone defects, such as lateral and vertical jaw ridge atrophies involves the use of autologous bone block grafts. A large drawback of this procedure is the need of a secondary surgery site, causing increased patient discomfort, risk and costs. The present project will therefore aim at the development of a shapeable synthetic bone repair material, which consists of a novel and innovative combination of a synthetic ceramic scaffold and hydrogel matrix serving as signaling factor carrier system to facilitate the repair of bone defects. The resulting product will be a novel bone graft in block form for critical size defects with osteogenic characteristics equivalent to autologous bone, or even better with respect to resorption resistance properties. It will offer a substantial potential in dentistry to augment the jaw bone and hence, allow the successful as well as cost saving dental implant treatment without additional risk and pain for the patient.

Abstract (English)

In oral surgery, the treatment of large bone defects, such as lateral and vertical jaw ridge atrophies involves the use of autologous bone block grafts. A large drawback of this procedure is the need of a secondary surgery site, causing increased patient discomfort, risk and costs. The present project will therefore aim at the development of a shapeable synthetic bone repair material, which consists of a novel and innovative combination of a synthetic ceramic scaffold and hydrogel matrix serving as signaling factor carrier system to facilitate the repair of bone defects. The resulting product will be a novel bone graft in block form for critical size defects with osteogenic characteristics equivalent to autologous bone, or even better with respect to resorption resistance properties. It will offer a substantial potential in dentistry to augment the jaw bone and hence, allow the successful as well as cost saving dental implant treatment without additional risk and pain for the patient.