Neuroprotection in stroke: field of application of XG-102 and development a novel multi-target neuroprotective compound.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 8909.1;5 PFLS-LS
• Titre du projet anglais: Neuroprotection in stroke: field of application of XG-102 and development a novel multi-target neuroprotective compound.

Description succincte (Anglais)

Neuroprotection in stroke: field of application of XG-102 and development a novel multi-target neuroprotective compound.

Description succincte (Français)

Neuroprotection in stroke: field of application of XG-102 and development a novel multi-target neuroprotective compound.

Résumé des résultats (Abstract) (Français)

XG-102 is a powerful neuroprotectant in rodent models of cerebral ischemia, with a safe toxicological profile (CTI # 7057.02). Ischemic damage progresses with time, so early treatment is important. Our experiments are aimed at proving that XG-102 is not detrimental in hemorrhagic stroke and does not interfere with thrombolysis, the currently available acute treatment of ischemic stroke. XG-102 could then be given indiscriminately to all stroke patients before reaching the hospital, saving 1-2 h and increasing the chances to protect the brain efficiently. Furthermore, the most efficient therapies will probably require the need of different drugs able to block the different cell death programs of the cells. Therefore, we will develop a novel multi-target neuroprotective compound.