Functionalized Titanium Surfaces for Biomedical Applications

Fonte Standard Gras
Identifiant

Unité de recherche

INNOSUISSE

Numéro de projet

7404.2;8 LSPP-LS

Titre du projet

Functionalized Titanium Surfaces for Biomedical Applications

Titre du projet anglais

Functionalized Titanium Surfaces for Biomedical Applications

Textes relatifs à ce projet

	Allemand	Français	Italien	Anglais
Description succincte	-	-	-
Résumé des résultats (Abstract)	-	-	-

Textes saisis

Catégorie	Texte
Description succincte (Anglais)	Functionalized Titanium Surfaces for Biomedical Applications
Résumé des résultats (Abstract) (Anglais)	The project aims at developing a novel titanium-based dental implant surface based on the presentation of bioactive ligands that elicit specific interface responses with a number of relevant cell types. Preliminary results demonstrate the feasibility of such surfaces to steer osteoblast cell attachment, proliferation and differentiation while at the same repelling bacteria. The study will comprise a matrix of interaction in vitro between synthetic peptides and four different cell types as well as five types of bacteria. In a second phase of the project, selected peptide-functionalized surfaces will be combined with a drug delivery system based on submicrometer carriers embedded and protected in the microstructured titanium implant surface for controlled release of bioactive species. Small animal studies for screening the osseointegration ability will complement the study. A specifically indicated application of the new implant surface will be for patients with immuno deficiencies (osteoporosis, diabetes).

Catégorie

Texte

Description succincte
(Anglais)

Functionalized Titanium Surfaces for Biomedical Applications

Résumé des résultats (Abstract)
(Anglais)

The project aims at developing a novel titanium-based dental implant surface based on the presentation of bioactive ligands that elicit specific interface responses with a number of relevant cell types. Preliminary results demonstrate the feasibility of such surfaces to steer osteoblast cell attachment, proliferation and differentiation while at the same repelling bacteria. The study will comprise a matrix of interaction in vitro between synthetic peptides and four different cell types as well as five types of bacteria. In a second phase of the project, selected peptide-functionalized surfaces will be combined with a drug delivery system based on submicrometer carriers embedded and protected in the microstructured titanium implant surface for controlled release of bioactive species. Small animal studies for screening the osseointegration ability will complement the study. A specifically indicated application of the new implant surface will be for patients with immuno deficiencies (osteoporosis, diabetes).