The use of MegaFasL in autologous hematopoietic transplantation

• Unité de recherche: INNOSUISSE
• Numéro de projet: 7244.1;5 LSPP-LS
• Titre du projet anglais: The use of MegaFasL in autologous hematopoietic transplantation

Description succincte (Anglais)

The use of MegaFasL in autologous hematopoietic transplantation

Description succincte (Français)

The use of MegaFasL in autologous hematopoietic transplantation

Résumé des résultats (Abstract) (Français)

MegaFasL is a humanized soluble protein that triggers apoptosis in target cells through engagement of the death receptor Fas. MegaFasL has an ideal profile as a cell purging agent in autologous hematopoietic transplantation. The proposed project will determine the potential of MegaFasL to rapidly enter the market as a novel cell purging compound by assessing its ability to selectively kill hematopoietic cancer cells while allowing repopulating stem cells and immune cells to remain functional.