MEDICAL DIAGNOSTIC BY MACROMIZER MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

Fonte Standard Gras
Identifiant

Unité de recherche

INNOSUISSE

Numéro de projet

7138.2;5 LSPP-LS

Titre du projet

MEDICAL DIAGNOSTIC BY MACROMIZER¿ MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

Titre du projet anglais

MEDICAL DIAGNOSTIC BY MACROMIZER¿ MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

Textes relatifs à ce projet

	Allemand	Français	Italien	Anglais
Description succincte	-	-	-
Résumé des résultats (Abstract)	-	-	-

Textes saisis

Catégorie	Texte
Description succincte (Anglais)	MEDICAL DIAGNOSTIC BY MACROMIZER MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS
Résumé des résultats (Abstract) (Anglais)	Early recognition of the development of a disease like cardiovascular disorders or cancer increases enormously the survival rate of patients and is decreasing dramatically the healing costs, accordingly the financial burdens on the health insurance system is reduced. This project aims at the development of a generally applicable strategy allowing the early discovery, detection and relative quantification of protein biomarkers in biological samples like body fluids or tissue biopsies. A two-dimensional, orthogonal protein fractionation strategy will be coupled with differential mass tagging of intact proteins prior to mass spectrometric detection of the proteins on the macromizer¿ MALDI-MS platform.

Catégorie

Texte

Description succincte
(Anglais)

MEDICAL DIAGNOSTIC BY MACROMIZER MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

Résumé des résultats (Abstract)
(Anglais)

Early recognition of the development of a disease like cardiovascular disorders or cancer increases enormously the survival rate of patients and is decreasing dramatically the healing costs, accordingly the financial burdens on the health insurance system is reduced. This project aims at the development of a generally applicable strategy allowing the early discovery, detection and relative quantification of protein biomarkers in biological samples like body fluids or tissue biopsies. A two-dimensional, orthogonal protein fractionation strategy will be coupled with differential mass tagging of intact proteins prior to mass spectrometric detection of the proteins on the macromizer¿ MALDI-MS platform.