MEDICAL DIAGNOSTIC BY MACROMIZER¿ MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

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Research unit

INNOSUISSE

Project number

7138.2;5 LSPP-LS

Project title

MEDICAL DIAGNOSTIC BY MACROMIZER¿ MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

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Short description (English)	MEDICAL DIAGNOSTIC BY MACROMIZER MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS
Abstract (English)	Early recognition of the development of a disease like cardiovascular disorders or cancer increases enormously the survival rate of patients and is decreasing dramatically the healing costs, accordingly the financial burdens on the health insurance system is reduced. This project aims at the development of a generally applicable strategy allowing the early discovery, detection and relative quantification of protein biomarkers in biological samples like body fluids or tissue biopsies. A two-dimensional, orthogonal protein fractionation strategy will be coupled with differential mass tagging of intact proteins prior to mass spectrometric detection of the proteins on the macromizer¿ MALDI-MS platform.

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Text

Short description
(English)

MEDICAL DIAGNOSTIC BY MACROMIZER MASS SPECTROMETRY ENABLED BY ACCURATE, 2-DIMENSIONAL PROTEIN SEPARATION TECHNOLOGY IN COMBINATION WITH CHEMICAL TAGGING OF PROTEINS

Abstract
(English)

Early recognition of the development of a disease like cardiovascular disorders or cancer increases enormously the survival rate of patients and is decreasing dramatically the healing costs, accordingly the financial burdens on the health insurance system is reduced. This project aims at the development of a generally applicable strategy allowing the early discovery, detection and relative quantification of protein biomarkers in biological samples like body fluids or tissue biopsies. A two-dimensional, orthogonal protein fractionation strategy will be coupled with differential mass tagging of intact proteins prior to mass spectrometric detection of the proteins on the macromizer¿ MALDI-MS platform.