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Forschungsstelle
INNOSUISSE
Projektnummer
7966.1;5 LSPP-LS
Projekttitel
Preclinical development of a humanized scFv antibody for prevention and treatment of Alzheimer¿s disease
Projekttitel Englisch
Preclinical development of a humanized scFv antibody for prevention and treatment of Alzheimer¿s disease

Texte zu diesem Projekt
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Kurzbeschreibung
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Abstract
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Erfasste Texte


KategorieText
Kurzbeschreibung
(Englisch)
Preclinical development of a humanized scFv antibody for prevention and treatment of Alzheimer¿s disease
Abstract
(Englisch)
The objective of this collaboration is the preclinical development of a humanized antibody, in particular a humanized single-chain (scFv) antibody fragment for the treatment and prevention of Alzheimer¿s Disease. For this reason the mechanism of action of various antibody fragments as well as pharmacokinetic and pharmacodynamic properties of an existing lead antibody (ESBA212), the latter resulting from a scientific collaboration between Prof. Nitsch and ESBATech, shall be characterized in detail in vivo in animal models of passive immunization of Alzheimer¿s Disease.