Functional assays for membrane proteins using nanopore array supports (MEMNA)

• Unité de recherche: INNOSUISSE
• Numéro de projet: 7644.2;6 NMPP-NM
• Titre du projet anglais: Functional assays for membrane proteins using nanopore array supports (MEMNA)

Description succincte (Allemand)

Funktionstests für Membranproteine auf Trägern mit Nanoporen (MEMNA)

Description succincte (Anglais)

Functional assays for membrane proteins using nanopore array supports (MEMNA)

Résumé des résultats (Abstract) (Allemand)

Lipid bilayer membranes immobilized on solid supports are relatively stable but at the cost of a restricted mobility whereas free-standing black lipid membranes in openings are fluidic but not very stable. We plan to investigate systematically the stability of free-standing lipid bilayers in pores of nanometer dimensions aimed at achieving both, a high stability and a high mobility of the lipid bilayer providing the basis for the development of functional assays for integral membrane proteins using nanopore array supports.

Résumé des résultats (Abstract) (Anglais)

Lipid bilayer membranes immobilized on solid supports are relatively stable but at the cost of a restricted mobility whereas free-standing black lipid membranes in openings are fluidic but not very stable. We plan to investigate systematically the stability of free-standing lipid bilayers in pores of nanometer dimensions aimed at achieving both, a high stability and a high mobility of the lipid bilayer providing the basis for the development of functional assays for integral membrane proteins using nanopore array supports.