Functional assays for membrane proteins using nanopore array supports (MEMNA)

• Research unit: INNOSUISSE
• Project number: 7644.2;6 NMPP-NM

Short description (German)

Funktionstests für Membranproteine auf Trägern mit Nanoporen (MEMNA)

Short description (English)

Functional assays for membrane proteins using nanopore array supports (MEMNA)

Abstract (German)

Lipid bilayer membranes immobilized on solid supports are relatively stable but at the cost of a restricted mobility whereas free-standing black lipid membranes in openings are fluidic but not very stable. We plan to investigate systematically the stability of free-standing lipid bilayers in pores of nanometer dimensions aimed at achieving both, a high stability and a high mobility of the lipid bilayer providing the basis for the development of functional assays for integral membrane proteins using nanopore array supports.

Abstract (English)

Lipid bilayer membranes immobilized on solid supports are relatively stable but at the cost of a restricted mobility whereas free-standing black lipid membranes in openings are fluidic but not very stable. We plan to investigate systematically the stability of free-standing lipid bilayers in pores of nanometer dimensions aimed at achieving both, a high stability and a high mobility of the lipid bilayer providing the basis for the development of functional assays for integral membrane proteins using nanopore array supports.