Management of peritoneal dyalysis toxicity

• Unité de recherche: INNOSUISSE
• Numéro de projet: 7576.2;5 LSPP-LS
• Titre du projet anglais: Management of peritoneal dyalysis toxicity

Description succincte (Anglais)

Management of peritoneal dyalysis toxicity

Description succincte (Français)

Management of peritoneal dyalysis toxicity

Résumé des résultats (Abstract) (Français)

Peritoneal dialysis (PD) has become a well established tool for the treatment of patients suffering from advanced kidney failure (see annex 1). Its widespread use is presently hampered in several instances by a progressive loss of efficiency. Within the framework of the CTI project ¿Chronodial¿ No 6169.2 MTS, a new mathematical model and computer simulation environment have been elaborated to investigate and predict the kinetics of individual injection-extraction patterns (see annex 3 and annex 4). Based on the remark that the long-term alterations of the peritoneal membrane are mostly induced by the presence of the dialysate, in this new project we propose a prescription mode of PD that takes into account the efficiency of blood purification (in the sense of small solute removal and ultrafiltration) as well as its potential bio-incompatibility and long-term toxicity.