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Research unit
TPH
Project number
8.09
Project title
Toward rabies free Sahelian cities, N'Djaména, Chad; The influence of demographic, spatial and behavioural heterogeneities in a urban domestic dog population on rabies transmission and control in Iringa, Tanzania

Texts for this project

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Key words
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Short description
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Project aims
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Key words
(German)
Urbane Tollwut, lichtmikroskopischer Antikörpertest, deterministisches Übertragungsmodell, Analyse der Kosten-Effizienz, Tschad, Mali, Tansania
Key words
(English)
Dog rabies, direct rapid immunohisto-chemical test, deterministic transmission model, cost-effectiveness analysis, Chad, Mali, Tanzania
Short description
(English)

Rabies is still an important zoonosis in many developing countries. The post-exposure treatment (the only way to save infected people) is expensive and often not available. On demand by Chadian authorities a partnership between the Swiss Tropical Institute with the Laboratoire de Recherches Vétérinaires et Zootechnique de Farcha and the Centre de Support en Santé International au Tchad was established. Thereby, a rabies laboratory with an immunofluorescence microscope was installed and a demographic study was organised in N'Djaména, the capital of Chad. In a pilot parenteral vaccination campaign, it was demonstrated that the proportion of ownerless dogs was below 10% and that vaccination coverage of 70% could be achieved. Our present research question is: What is the best and most cost-effective strategy to eliminate rabies in N‘Djaména, Chad? We hypothesize, that periodical parenteral vaccination of the dog populations is probably the most cost-effective, acceptable and feasible method to control rabies in urban settings of African cities.

The aim of the study in Tanzania is to describe the demography, spatial distribution, behaviour and accessibility of urban domestic dogs and local dog-management, in order to assess the importance and influence of these factors on transmission as well as control of rabies, and eventually to help finding easily applicable methods to achieve a well designed and community fitted rabies-control. The study was conducted in collaboration with the Centre for Tropical Veterinary Medicine, Edinburgh and with the Sokoine University, Morogoro, and the fieldwork was done in Iringa from April to December 2004.

Project aims
(English)

Components of this work are:

  • To estimate demographic parameters of dog populations to develop a new dog-human rabies transmission model and validate it on field data. With this model it is possible to simulate different strategies of rabies-control (vaccination, elimination of dogs).
  • To assess willingness to pay of dog owners to vaccinate their dog to investigate cost-sharing scenarios.
  • To establish and validate a new rabies diagnostic test (developed by the Centres of Disease Control and Preventation (CDC) in Atlanta, USA) that works with a normal light microscope.
  • To compare the incidence of dog rabies with biting statistics in hospitals as an indirect indicator of dog rabies incidence
  • To assess and describe the accessibility of domestic dogs for vaccination campaigns, which includes an estimation of the number of inaccessible dogs to calculate the vaccination coverage reached in the campaign and to identify potential core spreader characteristics.
  • To assess and describe the demographic, spatial and behavioural heterogeneities in urban domestic dog populations and their influence on the design of rabies control programs.
  • To assess and describe the influence of local perception of the feral dog population and the local attitude towards dog keeping and how these influence the design of rabies control programs.