Description succincte
(Anglais)
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A network dedicated to the synthesis of biologically active alkaloids has been created. The working group will consist of six groups specialized in the synthesis together with a group developing biological assays for tubulin interactions and a group active in the isolation of natural products from tropical plants. The target molecules have been chosen according to their biological activities (cancer and malaria treatment, glycosidase inhibitors, imunosuppressants, etc.). At the University of Berne, a novel strategy for the preparation of Cephalotaxus alkaloids will be developed.
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Partenaires et organisations internationales
(Anglais)
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BE, BG, CY, CZ, DK, FI, FR, DE, EL, HU, IS, IE, IL, IT, LV, NO, RO, SK, ES, SE, CH, UK
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Résumé des résultats (Abstract)
(Anglais)
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Indolizidines, cephalotaxines and lepadiformines, are three different classes of alkaloids with biological activities that are potentially attractive to fight several forms of cancer. A general approach for their preparation using a radical carboazidation has been developed. A fruitfull collaboration with the group of Y. Landais in Bordeaux (France) has been established and will be pursued beyond the COST D28 Action. A second strategy involving a radical 1,5-hydrogen transfer process has also been developed. This approach involves a collaboration with the group of F. Rutjes in Nijmegen (Holland).
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