Titel
Accueil
Navigation principale
Contenu
Recherche
Aide
Fonte
Standard
Gras
Identifiant
Interrompre la session?
Une session sous le nom de
InternetUser
est en cours.
Souhaitez-vous vraiment vous déconnecter?
Interrompre la session?
Une session sous le nom de
InternetUser
est en cours.
Souhaitez-vous vraiment vous déconnecter?
Accueil
Plus de données
Partenaires
Aide
Mentions légales
D
F
E
La recherche est en cours.
Interrompre la recherche
Recherche de projets
Projet actuel
Projets récents
Graphiques
Identifiant
Titel
Titel
Unité de recherche
PCRD EU
Numéro de projet
03.0570-1
Titre du projet
MUVAPRED: Mucosal vaccines for poverty related diseases
Titre du projet anglais
MUVAPRED: Mucosal vaccines for poverty related diseases
Données de base
Textes
Participants
Projets afférents
Titel
Textes relatifs à ce projet
Allemand
Français
Italien
Anglais
Mots-clé
-
-
-
Autre Numéro de projet
-
-
-
Programme de recherche
-
-
-
Description succincte
-
-
-
Résumé des résultats (Abstract)
-
-
-
Références bases de données
-
-
-
Textes saisis
Catégorie
Texte
Mots-clé
(Anglais)
Mucosal vaccines; Mycobacterium tuberculosis; tuberculosis; HIV; AIDS
Autre Numéro de projet
(Anglais)
EU project number: 503240
Programme de recherche
(Anglais)
EU-programme: 6. Frame Research Programme - 1.1.2c
Description succincte
(Anglais)
See abstract
Résumé des résultats (Abstract)
(Anglais)
This project is focused on the development of mucosal vaccines against AIDS and tuberculosis (TB) and is based on the use of antigens validated as safe and effective in animal models. Mucosal vaccines present advantages of practical and' social relevance when compared to parenteral. To ensure vaccine compliance, accessibility, and coverage, vaccines should be designed which can be administered by convenient mucosal routes of delivery. Mucosal vaccines, inducing both local and systematic immune responses, are considered more effective in controlling mucosally-acquired infections, such as HIV and TB.
The project consists of two major parallel interlinked tracks: (i) phase I trials of mucosal immunization using antigens and adjuvants validated in previous preclinical and clinical studies (ii) development of new candidate vaccines for mucosal immunization and their comparative selection in animal models. Antigens such as GAg, V2-deleted gp 120, Tat (HIV-l), and Ag85B/ESAT-6 hybrid molecule (TB), and adjuvants such as LTK63 and HSP70, will be used in combination for phase I trials to be performed first in Europe and then in Africa.
Development of new vaccine candidates will not include antigen discovery but would rather be based on the novel use of adjuvants and delivery systems in combination with promising antigens. Animal models of increasing relevance for human vaccines will be used to compare new candidates and to select those which should proceed to phase I trials.
The final expected result of this Project is to provide candidate mucosal vaccines, with proved safety and immunogenicity in humans, that could subsequently enter the path towards licensure through phase II and III clinical trials. The European Developing Countries Clinical Trials Partnership which is expected to be soon operative could be instrumental in exploiting the results obtained in this project by testing mucosal vaccines against these devasting diseases in developing countries.
Références bases de données
(Anglais)
Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. +41 31 322 74 82
Swiss Project-Number: 03.0570-1
SEFRI
- Einsteinstrasse 2 - 3003 Berne -
Mentions légales