Kurzbeschreibung
(Englisch)
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First, we want to examine a number of complexes of ruthenium and of other group VIII transition metals in order to set up a sequence of experimental assays in vitro which allow to predict selective antimetastatic activity in vivo. Second, we intend to identify the nature and the biological relevance for the interaction of ruthenium complexes with the components of the extracellular matrix. Third, we want to ascertain the existence of a cell membrane receptor for ruthenium complexes, responsible for the non cytotoxic effects on solid tumour metastases. The ultimate goal of this study is that of identifying a chemical structure and a biological target for the selective treatment of solid tumour metastases by interfering with the mechanism that sustain the malignant growth. The group of laboratories of the present proposal represent a wide and integrated competence of inorganic compounds which may allow the identification of a new strategy for the study of novel metal-based drugs in cancer chemotherapy.
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Partner und Internationale Organisationen
(Englisch)
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AT, BE, BG, CZ, DK, FI, FR, DE, EL, HU, IE, IL, IT, NL, NO, PL, RO, SI, ES, SE, CH, TR, UK
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