PROSAFE: Biosafety evaluation of probiotic lactic acid bacteria used for human consumption

• Unité de recherche: PCRD EU
• Numéro de projet: 03.0118
• Titre du projet anglais: PROSAFE: Biosafety evaluation of probiotic lactic acid bacteria used for human consumption

Mots-clé (Anglais)

Agriculture; Economic Aspects; Food; Industrial Manufacture; Life Sciences; Medicine; Health; Safety

Autre Numéro de projet (Anglais)

EU project number: QLK1-CT-2001-01273

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.1 Food, nutrition and health

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Université de Lausanne
Département de microbiologie fondamentale DMF
Bâtiment Biophore

Résumé des résultats (Abstract) (Anglais)

Probiotic bacteria, mainly lactic acid bacteria (LAB) (e.g. lactobacilli, iactococci, enterococci, and bifidobacteria) have been considered safe for human consumption. However, recent reports of clinical infection, the spread of antibiotic resistance genes, and development of new and/or modified probiotic LAB strains, have caused concern of safety. This project aims to assess the bio-safe of LAB. Isolates from healthy humans and immuno-compromised patients, commercially available and new probiotic LAB will be studied.

After poly-phasic taxonomic identification, their bio-safety will be assessed by:
i) the detection of antibiotic resistance and horizontal transfer of antibiotic resistance genes;
ii) the detection of known and new virulence properties;
iii) evaluation of immunological adverse effects of LAB;
iv) the survival, colonisation, and genetic stability of probiotic LAB in the human gut. The project will result in recommendations for bio-safe and bio-safety testing ofLAB, which will be presented and discussed at a final conference.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 03.0118