TRANSEUROPE: Predicting outcome and developing new therapeutic strategies for haematological stem cell transplant recipients using in vitro techniques

• Unité de recherche: PCRD EU
• Numéro de projet: 03.0022
• Titre du projet anglais: TRANSEUROPE: Predicting outcome and developing new therapeutic strategies for haematological stem cell transplant recipients using in vitro techniques

Mots-clé (Anglais)

Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Autre Numéro de projet (Anglais)

EU project number: QLK3-CT-2002-01936

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Hôpitaux universitaires de Genève HUG
Département de Dermatologie

Résumé des résultats (Abstract) (Anglais)

Allogeneic stem cell transplantation (SCT) is the only means of cure for haematological malignancies, as well as congenital anaemias and immunodeficiency disorders. The current poor rate of survival (30-50%) is due to post transplant complications, including infectious episodes, relapse (a lack of a graft versus leukaemia (GvL) effect) and graft versus host disease (GvHD). Tools to predict acute and chronic GvHD and/or GvL following different types of allogeneic SCT would enable new clinical protocols and therapeutics strategies to be developed based on individual patient expected risk. By the use of in vitro biotechnology. Genetic and clinical risk assessments, we aim to predict outcome following therapy and SCT; develop new Europe-wide common clinical protocols and improve current therapeutic strategies. The project involves the development of an important Europe-wide tissue bank for research use within the transplant community.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 03.0022