TRANSEUROPE: Predicting outcome and developing new therapeutic strategies for haematological stem cell transplant recipients using in vitro techniques

• Forschungsstelle: EU FRP
• Projektnummer: 03.0022
• Projekttitel Englisch: TRANSEUROPE: Predicting outcome and developing new therapeutic strategies for haematological stem cell transplant recipients using in vitro techniques

Schlüsselwörter (Englisch)

Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Alternative Projektnummern (Englisch)

EU project number: QLK3-CT-2002-01936

Forschungsprogramme (Englisch)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Kurzbeschreibung (Englisch)

See abstract

Weitere Hinweise und Angaben (Englisch)

Full name of research-institution/enterprise:
Hôpitaux universitaires de Genève HUG
Département de Dermatologie

Abstract (Englisch)

Allogeneic stem cell transplantation (SCT) is the only means of cure for haematological malignancies, as well as congenital anaemias and immunodeficiency disorders. The current poor rate of survival (30-50%) is due to post transplant complications, including infectious episodes, relapse (a lack of a graft versus leukaemia (GvL) effect) and graft versus host disease (GvHD). Tools to predict acute and chronic GvHD and/or GvL following different types of allogeneic SCT would enable new clinical protocols and therapeutics strategies to be developed based on individual patient expected risk. By the use of in vitro biotechnology. Genetic and clinical risk assessments, we aim to predict outcome following therapy and SCT; develop new Europe-wide common clinical protocols and improve current therapeutic strategies. The project involves the development of an important Europe-wide tissue bank for research use within the transplant community.

Datenbankreferenzen (Englisch)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 03.0022