RESMALCHIP: Development of a malaria resistance DNA chip as a public health tool for the management of plasmodium falciparum malaria drug resistance

• Unité de recherche: PCRD EU
• Numéro de projet: 03.0001
• Titre du projet anglais: RESMALCHIP: Development of a malaria resistance DNA chip as a public health tool for the management of plasmodium falciparum malaria drug resistance

Mots-clé (Anglais)

Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Autre Numéro de projet (Anglais)

EU project number: QLK-2-CT-2002-01503

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Description succincte (Anglais)

See abstract

Résumé des résultats (Abstract) (Anglais)

Genetic diversity of malaria parasites is a major obstacle to develop rational control strategies against this poverty related disease. Increase of health threatening drug resistance must be monitored and prevented to protect introduced drugs. We propose to evaluate a newly developed DNA micro arrays for drug resistance monitoring in affected areas. Results will allow to capture dynamics of drug resistance and to forecast its development by establishing a community based Genetic Resistance Index, providing tools for rational and evidence based decisions on optimal use of drugs. We will assess the relationship between in vivo drug sensitivity and in vitro susceptibility to several anti-malarials and prevalence of multiple SNPs providing correlates for clinical resistance. Sequencing will identify additional informative codons. We will also explore pftctp as a potential marker for resistance to artemisin in derivatives.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 03.0001