EUPEAH: Glucocorticoid Hormone Programming in Early Life and its Impact on Adult Health

• Unité de recherche: PCRD EU
• Numéro de projet: 02.0440
• Titre du projet anglais: EUPEAH: Glucocorticoid Hormone Programming in Early Life and its Impact on Adult Health

Mots-clé (Anglais)

Life Sciences; Scientific Research

Autre Numéro de projet (Anglais)

EU project number: QLRI-CT-2002-02758

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.9 Support for research infrastructures

Description succincte (Anglais)

See abstract

Résumé des résultats (Abstract) (Anglais)

Low birth weight in humans is associated with increased risk of hypertension, diabetes or affective disorders in later life. Excessive foetal exposure to gluco corticoids (GCs) retards organism growth, as GCs exert prenatal programming in a variety of target tissues. Whilst many researchers have argued on the basis of conventional animal models to explain the links between prenatal GC exposure and the commonest human disorders, none has shown strict relevance to humans. To elucidate the mechanisms in a primate model, we propose extending the studies in rats to marmoset monkeys. The animals will be treated prenatal with GCs, studying the impact upon potential adverse metabolic programming, reproductive and immune function, HPA axis activity, brain function and morphology and behaviour. Understanding how such prenatal programming works provides prospects for disease prevention and health promotion.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 02.0440