REPBIOTECH: DNA replication and biotechnological applications

• Research unit: EU RFP
• Project number: 02.0286

Key words (English)

Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Alternative project number (English)

EU project number: QLRT-2001-02071

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Short description (English)

See abstract

Abstract (English)

DNA replication is a key process involved in cell division of all living creatures. Based on the structural and functional homology between archaea and eukaryotes, this project proposes to co-or donate efforts of one SME and seven laboratories from five European countries on the characterisation of DNA replication components, DNA Polymerases, accessory proteins, both in archaea and Human.

Each step of DNA replication will be investigated, initiation, elongation and processing of the lagging strand in order:
i) to understand the basic mechanisms at each level;
ii) to isolate novel proteins and enzymes and;
iii) to increase the probability of finding new products and key residues. Two fields of application are concerned: molecular biology products in vitro amplification and health with novel DNA replication inhibitors.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 02.0286