ESCAPE: Molecular mechanisms of disease progression and renoprotective pharmacotherapy in children with chronic renal failure

• Research unit: EU RFP
• Project number: 02.0277

Key words (Italian)

Life Sciences; Medicine; Health; Scientific Research

Alternative project number (English)

EU project number: QLG1-CT-2002-00908

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Kinderspital Zürich Eleonorenstiftung / Universitäts-Kinderklinik

Abstract (English)

ACE inhibitors are renoprotective in adults with chronic renal failure (CRF), but of unproven usefulness in children. In a randomized trial in 350 CRF children we will address if ACE inhibition is efficacious in slowing CRF progression in acquired and congenital nephropathies, if progression can be additionally influenced by intensified antihypertensive treatment achieving low-normal blood pressure, and which factors determine CRF progression and/or its susceptibility to ACE inhibition. Potential effects of renin-angiotensin system and PAI-l gene polymorphisms, mutations in genes defining glomerular structure or causing renal hypo/dysplasia, renal endothelnr-l turnover, plasma homocysteine and apolipoprotein phenotypes will be assessed. The cardiovascular consequences of childhood-onset CRF and renoprotective pharmacotherapy will be addressed bycarotid ultrasound, echocardiography and 24-hour blood presssure moritoring.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 02.0277