PARADIGM: Pararetroviruses : disease, integration and genomes

• Unité de recherche: PCRD EU
• Numéro de projet: 02.0261
• Titre du projet anglais: PARADIGM: Pararetroviruses : disease, integration and genomes

Mots-clé (Anglais)

Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Autre Numéro de projet (Anglais)

EU project number: QLK3-CT-2002-02098

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Description succincte (Anglais)

See abstract

Résumé des résultats (Abstract) (Anglais)

Following the recent discovery that many plant genomes harbour endogenous pararetrovirus (EPRV) sequences, the PARADIGM proposal aims at:
i) investigating the biodiversrty and evolutionary status of EPRVs in crops of economic importance to European agriculture;
ii) screening such economically important crops for possibly deleterious EPRVs;
iii) evaluating the risks of EPRVs for ongoing and future breeding programs, mass production of vegetatively propagated plants and germplasm conservation;
iv)determining the mechanisms of integration, activation, excision and expression of EPRVs leading to infectious episomal viral genomes;
v) defining the effect of EPRVs on the stability and dynamics of plant genomes and;
vi)characterising mechanisms, such as gene silencing, developed by plants to control EPRVs and strategies developed by PRVs to suppress such controls.

These projects will ultimately lead to the development of new risk assessment and control strategies for EPRVs, and to the implementation of such strategies through industrial partnerships with European plant biotechnology and plant breeding small and medium enterprises (SMEs).

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 02.0261