DRUGLORESYS: Drug loading of implant surfaces with local controlled release system

• Research unit: EU RFP
• Project number: 02.0057

Key words (English)

Industrial Manufacture; Materials Technology

Alternative project number (English)

EU project number: G5RD-CT-2001-00532

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.3.8 Generic R&D activities

Short description (English)

See abstract

Abstract (English)

This proposal deals with the development of a technology for drug loading and a controlled release system on the surface of a metal implant. Five promising coating technologies will be examined in order to develop this loading and releasing technology. The research will be done on a generic surface and finally result in the development of a prototype implant. In Drugloresys a complex implant surface was chosen for this purpose, namely a stent to be placed in the vessel of a patient whose vessels are narrowed due to plaque. Vascular diseases are in 40% the cause of death in the EU, as the narrowing of vessels (restenosis) lead to heart attacks as well as strokes. A promising method to reduce the amount of restenosis would be a drug-coated stent, releasing drugs locally. The impact of a solution for local drug delivery in vascular diseases is high, but also the future application areas are most promising, such as oncology and diabetes as well as orthopaedic surgery.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 02.0057