X-TB: Structure and functional genomics of mycobacterium tuberculosis

• Research unit: EU RFP
• Project number: 02.0035

Key words (English)

Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Alternative project number (English)

EU project number: QLK2-CT-2001-02018

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
EPF Lausanne
Institut de chimie moléculaire et biologique
BCH

Abstract (English)

As a result of demographic changes, political and social instability, air travel and globalisation, the EU is increasingly threatened by tuberculosis, a chronic respiratory disease that respects no frontiers. The current treatment requires modernisation to improve efficacy and tolerance, and to combat problems of resistance. In this project, structural and functional genomics will be used as tools for drug discovery. Mycobacterial proteins that could serve as novel targets for chemotherapy will be identified, and inhibitors will either be isolated from libraries by using novel screens of natural or (semi) synthetic products or, by using 3D structures as templates for drug design. Other products arising from this proposal include expression libraries, large amounts of mycobacterial proteins, proteome and protein linkage maps, and dedicated databases.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 02.0035