CHECKPOINTS AND CANCER: Checkpoints, DNA damage response and cancer

• Unité de recherche: PCRD EU
• Numéro de projet: 01.0594
• Titre du projet anglais: CHECKPOINTS AND CANCER: Checkpoints, DNA damage response and cancer

Mots-clé (Anglais)

Education; Training; Scientific Research; Social Aspects

Autre Numéro de projet (Anglais)

EU project number: HPRN-CT-2002-00238

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 4.1.1 Research training networks

Description succincte (Anglais)

See abstract

Résumé des résultats (Abstract) (Anglais)

The DNA Damage Response (DDR) protects the genome from cytotoxic and mutagenic effects of chemicals and radiation in the environment. Genetic defects in DDR lead to genome instability and predispose individuals to diseases like cancer. DDRis a rapid, dynamic and integrated response to genome insult which co- ordinates cell cycle progression, DNA replication and DNA repair. Our understanding of DDR has been based largely on the use of specific approaches in specific model organisms: e.g. genetics in yeast, biochemistry in frogs, cytology in mammalian cells. The participating teams are experts with these model organisms who are committed to expanding their repertoire of technical and conceptual approaches to studying DDR.

Our objectives are:
- To characterise mechanisms of genome surveillance in response to DNA damage and DNA replication stress by studying several key components (PI(3)- related kinases and associated subunits, Sgs1 helicasef PCNA and RF-C-related DDR components);
- To examine the role of novel Components of the DNA damage signal transduction pathway;
- To characterise the downstream effects of DDR on DNA replication, chromatin structure and ubiquitin mediated proteolysis. In each case, a multidisciplinary approach will involve the study of processes and proteins in different organisms using different technical strategies. This unique European collaboration will lead to new advances and contribute to an integrated view of DDR in eukaryotic cells.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 01.0594