BIOMEX: Whole-cell Baeyer-Villiger Monooxygenase biocatalysts: methodologies of exploitation

• Research unit: EU RFP
• Project number: 01.0538

Key words (English)

Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; Waste Management

Alternative project number (English)

EU project number: QLT3-CT-2001-00403

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.9 Support for research infrastructures

Short description (English)

See abstract

Abstract (English)

This project is aimed at developing and applying novel methodologies for the exploitation of Baeyer-Villiger monooxygenase based bio-catalysis. In a framework4 programme (BIO4-CT98-0267) we have successfully shown that the use of these bi-catalysts is possible on a laboratory and pilot plant scale for the synthesis of optically pure lactones as useful synthetic reagents for a range of industrial products. However scale-up beyond this for industrial exploitation will require addressing a number of key bottlenecks. In this project we aim to address these bottlenecks with the objective of devising safe, efficient and environmentally compatible processes suitable for large-scale operation and to demonstrate this with the industrial partner at 50 and 1000 L scale. Additionally a systematic scale-up methodology will be demonstrated.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 01.0538