Key words
(English)
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Life Sciences; Medicine; Health; Scientific Research
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Alternative project number
(English)
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EU project number: QLG1-CT-2001-02007
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Research programs
(English)
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EU-programme: 5. Frame Research Programme - 1.1.6 The ageing population and disabilities
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Short description
(English)
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See abstract
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Further information
(English)
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Full name of research-institution/enterprise:
Hôpitaux universitaires de Genève HUG
Clinique de Dermatologie
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Abstract
(English)
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The project is aimed at a comprehensive analysis of the pathophysiology of a group of rare, but severe and chronic autoimmunebullous skin disorders, the pemphigoids (PEs), characterized by defective epithelial adhesion and auto antibodies against components of the skin basement membrane zone. These diseases represent a prototype of organ-specific autoimmune disorders which share common pathogenetic mechanisms. The objectives are: the analysis of molecular interactions and processing of epithelial adhesion proteins targets in the PEs; the characterization of the humoral immune responses and T cell immune responses in the PEs; the study of disease development risk factors.
Expected results are:
(i) a better understanding of the immuno-pathogenesis of PEs disorders;
(ii)the definition of markers for disease severity, progression and outcome;
(iii) the identification of subjects at risk for disease;
(iv) thedevelopment of new diagnostic tools and of;
(v) novel immuno-therapy for these diseases.
Altogether these results will also enhance understanding and allow development of new diagnostic and therapeutic approaches in other autoimmune disorders.
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References in databases
(English)
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Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. +41 31 322 74 82
Swiss Project-Number: 01.0113
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