LIFE/DEATH SIGNALS: Signalling for death and survival in neurons

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0074a
• Titre du projet anglais: LIFE/DEATH SIGNALS: Signalling for death and survival in neurons

Mots-clé (Anglais)

Life Sciences; Medicine; Health; Scientific Research

Autre Numéro de projet (Anglais)

EU project number: QLG3-CT-1999-00602

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Description succincte (Anglais)

See abstract

Résumé des résultats (Abstract) (Anglais)

Neuro-degenerative diseases represent a major social and economic problem for the Community; they are characterised by the cell death of specific populations of neurons. No cures currently exist: good candidates would be drugs that inhibit intracellular signalling pathways involved in cell death, or stimulate signalling for survival, but we know little about how these pathways are regulated in neurons in normal or pathological situations. Our transnational project involving academic, clinical and industrial partners is aimed at a better understanding of the role of several novel mechanisms. We will study in neurons the control mechanisms and signalling pathways involved. We aim to generate important new data in this fast-moving field, and to define novel potential targets for drug discovery.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0074a