LIFE/DEATH SIGNALS: Signalling for death and survival in neurons

• Research unit: EU RFP
• Project number: 00.0074a

Key words (English)

Life Sciences; Medicine; Health; Scientific Research

Alternative project number (English)

EU project number: QLG3-CT-1999-00602

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Short description (English)

See abstract

Abstract (English)

Neuro-degenerative diseases represent a major social and economic problem for the Community; they are characterised by the cell death of specific populations of neurons. No cures currently exist: good candidates would be drugs that inhibit intracellular signalling pathways involved in cell death, or stimulate signalling for survival, but we know little about how these pathways are regulated in neurons in normal or pathological situations. Our transnational project involving academic, clinical and industrial partners is aimed at a better understanding of the role of several novel mechanisms. We will study in neurons the control mechanisms and signalling pathways involved. We aim to generate important new data in this fast-moving field, and to define novel potential targets for drug discovery.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0074a