Quantification of antibody-prion protein-interactions in immunosandwiches.

Fonte Standard Gras
Identifiant

Unité de recherche

INNOSUISSE

Numéro de projet

6779.1;7 FHS-LS

Titre du projet

Quantification of antibody-prion protein-interactions in immunosandwiches

Titre du projet anglais

Quantification of antibody-prion protein-interactions in immunosandwiches

Textes relatifs à ce projet

	Allemand	Français	Italien	Anglais
Description succincte	-	-	-
Résumé des résultats (Abstract)	-	-	-

Textes saisis

Catégorie	Texte
Description succincte (Anglais)	Quantification of antibody-prion protein-interactions in immunosandwiches.
Résumé des résultats (Abstract) (Anglais)	BSE-tests presently on the market are based on the binding of the protease resistant part of the prion protein to specific antibodies. The immuno sandwich formed by a capture antibody, PrP and a detection antibody will be investigated by the label free surface plasmon resonance technique (SPR) to identify suitable pairs of antibodies and to find optimal binding conditions. This leads to enhanced sensitivity necessary for a live test.

Catégorie

Texte

Description succincte
(Anglais)

Quantification of antibody-prion protein-interactions in immunosandwiches.

Résumé des résultats (Abstract)
(Anglais)

BSE-tests presently on the market are based on the binding of the protease resistant part of the prion protein to specific antibodies. The immuno sandwich formed by a capture antibody, PrP and a detection antibody will be investigated by the label free surface plasmon resonance technique (SPR) to identify suitable pairs of antibodies and to find optimal binding conditions. This leads to enhanced sensitivity necessary for a live test.