Quantification of antibody-prion protein-interactions in immunosandwiches

Font Standard Bold
Login

Project search
Actual Project
Recent projects
Graphics
Login

Research unit

INNOSUISSE

Project number

6779.1;7 FHS-LS

Project title

Quantification of antibody-prion protein-interactions in immunosandwiches

Basic data
Texts
Participants

Texts for this project

	German	French	Italian	English
Short description	-	-	-
Abstract	-	-	-

Inserted texts

Category	Text
Short description (English)	Quantification of antibody-prion protein-interactions in immunosandwiches.
Abstract (English)	BSE-tests presently on the market are based on the binding of the protease resistant part of the prion protein to specific antibodies. The immuno sandwich formed by a capture antibody, PrP and a detection antibody will be investigated by the label free surface plasmon resonance technique (SPR) to identify suitable pairs of antibodies and to find optimal binding conditions. This leads to enhanced sensitivity necessary for a live test.

Category

Text

Short description
(English)

Quantification of antibody-prion protein-interactions in immunosandwiches.

Abstract
(English)

BSE-tests presently on the market are based on the binding of the protease resistant part of the prion protein to specific antibodies. The immuno sandwich formed by a capture antibody, PrP and a detection antibody will be investigated by the label free surface plasmon resonance technique (SPR) to identify suitable pairs of antibodies and to find optimal binding conditions. This leads to enhanced sensitivity necessary for a live test.