Statistical analysis of within-host dynamics of Plasmodium falciparum infections.

• Forschungsstelle: TPH
• Projektnummer: 6.06
• Projekttitel Englisch: Statistical analysis of within-host dynamics of Plasmodium falciparum infections.

Schlüsselwörter (Englisch)

Malaria, modeling, parasitaemia, Plasmodium

Kurzbeschreibung (Englisch)

With a view to estimating the duration of untreated malaria infection the project is carrying out: 1. Statistical analysis of data from a panel survey comprising 7 two-monthly samples from an age-stratified cohort of 300 individuals in the Kassena-Nankana District (KND) of northern Ghana (an area holoendemic for P. falciparum). 2. In collaboration with Prof. Dr. K. Dietz (University of Tübingen, Germany), additional analytical techniques are being developed to study the dynamics of infections in a panel dataset of msp-2 typing data from Kiberege, Tanzania, and also for the KND dataset. 3. Further analyses will consider whether these models can account for patterns of infection (determined by light microscopy) in the Garki project, an intensively monitored experiment in malaria eradication in northern Nigeria, carried out in 1971-1977. Similarly, data from the eradication project in West Papua reported by Metselaar (1957) and from the Pare-Taveta scheme in East Africa will be analysed.

Projektziele (Englisch)

The project addresses the questions of : what is the duration of untreated malaria infections in endemic areas? How does this vary depending on the age and exposure of the human host? and how is the incidence of malaria superinfection in endemic areas related to age and exposure?

Abstract (Englisch)

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Publikationen / Ergebnisse (Englisch)

Sama W, Killeen G, Smith, T. Estimating the duration of Plasmodium falciparum infection from trials of indoor residual spraying. American Journal of Tropical Medicine & Hygiene 70(6), 625-634, 2004.

Sama W, Owusu-Agyei S, Felger I, Vounatsou P, Smith T. An immigration-death model to estimate the duration of malaria infection when detectability of the parasite is imperfect. Stat Med.;24:3269-88, 2005.

Sama W, Dietz K., & Smith T. The Distribution of Survival Times of Deliberate Plasmodium Falciparum Infections in Tertiary Syphilis Patients. Trans R Soc Trop Med Hyg. 100, 811-816, 2006.

Sama W, Owusu-Agyei S., Felger I., Dietz K., & Smith T. Age and seasonal variation in the transition rates and detectability of Plasmodium falciparum malaria Parasitology: 132, 13-21, 2006.

Smith, T., Sama W.. Estimating the duration of common persistent infections. Pp 52-53 in Workshop: Design and Analysis of Infectious Disease Studies. Report No. 49/2004, Mathematisches Forschungsinstitut Oberwolfach, Germany, 2004.