Circumventing Product Toxicity - Development of a Novel Two-stage Production Process for the Antibiotic Gallidermin: Spatial and Temporal Separation of Biosynthesis and Activation

• Unité de recherche: INNOSUISSE
• Numéro de projet: 6675.1;8 BTS-LS
• Titre du projet anglais: Circumventing Product Toxicity - Development of a Novel Two-stage Production Process for the Antibiotic Gallidermin: Spatial and Temporal Separation of Biosynthesis and Activation

Description succincte (Allemand)

Circumventing Product Toxicity - Development of a Novel Two-stage Production Process for the Antibiotic Gallidermin: Spatial and Temporal Separation of Biosynthesis and Activation

Description succincte (Anglais)

Circumventing Product Toxicity - Development of a Novel Two-stage Production Process for the Antibiotic Gallidermin: Spatial and Temporal Separation of Biosynthesis and Activation

Résumé des résultats (Abstract) (Anglais)

We will investigate and develop a novel process concept for the production of gallidermin, a new type of antibiotic from Staphylococcus gallinarum with promising applications for treatment of systemic MRSA or topical Propionibacterium acne infections with a novel mode of action. Its high activity and the lack of resistance mechanisms require a completely new approach to make gallidermin production economical.