In vivo testing of different multimeric forms of ligands of the TNF family in cancers and immune-deregulation

• Research unit: INNOSUISSE
• Project number: 6578.1;10 BTS-LS

Short description (English)

In vivo testing of different multimeric forms of ligands of the TNF family in cancers and immune-deregulation

Short description (French)

In vivo testing of different multimeric forms of ligands of the TNF family in cancers and immune-deregulation

Abstract (English)

CD40 ligand (CD40L) is a member of the tumor-necrosis factor (TNF) family of proteins and a co-stimulator of immune responses. We propose to perform preclinical testing of an agonist of human CD40L (megaCD40L) using assays in vitro and in vivo mouse models of tumor immunotherapy. Fas ligand (FasL) is a pro-apoptotic member of the TNF superfamily. We have generated a highly active form of FasL (megaFasL). We will perform complete preclinical testing of megaFasL as a potential therapeutic for mesotheliomas