CELLSENS: Novel in-vitro testing platforms based on intra- and extracellular sensing

• Research unit: EU RFP
• Project number: 01.0120

Key words (English)

Electrochemical (bio)chemical microsensors; microelectrode arrays; intra- and extracellular detection; nitric oxide; superoxide; glutamate;
Biotechnology; Environmental Protection; Innovation; Technology Transfer; Life Sciences; Medicine; Health; W

Alternative project number (English)

EU project number: QLK3-CT-2001-00244

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Short description (English)

See abstract

Partners and International Organizations (English)

Coordinator: Lund University (S)

Abstract (English)

The goal of the project is to develop new in-vitro platforms for pharmaceutical screening based on animal or human cells grown on microelectrode arrays enabling simultaneous monitoring of extra- and intracellular levels of key metabolites (e.g., NO and super oxide) by using optico- electrochemical techniques. By individually addressing the electrodes of the arrays the toxicity of bio medically relevant substances can be studied with increased spatial resolution and without disturbing the living cells. The proposed in-vitro testing platforms address development of high throughput screening for detecting toxicity and development of in-vitro toxicity tests for assessing local toxicity and neuro-toxicology. By bringing together modern technologies a novel integrated generic measurement platform will be developed to monitor metabolites in cultured cell lines and primary cells, vital for rapid drug discovery.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 01.0120