IMPCSF: Immunological mechanisms of protection against classical swine fever virus: towards the development of new efficacious marker vaccines

• Unité de recherche: PCRD EU
• Numéro de projet: 00.0635
• Titre du projet anglais: IMPCSF: Immunological mechanisms of protection against classical swine fever virus: towards the development of new efficacious marker vaccines

Mots-clé (Anglais)

Classical swine fever; immunological mechanisms; innate immunity; marker vaccine;
Life Sciences; Medicine; Health; Safety; Scientific Research; Social Aspects

Autre Numéro de projet (Anglais)

EU project number: QLK2-CT-2001-01374

Programme de recherche (Anglais)

EU-programme: 5. Frame Research Programme - 1.1.2 Control of infectious diseases

Description succincte (Anglais)

See abstract

Autres indications (Anglais)

Full name of research-institution/enterprise:
Bundesamt für Veterinärwesen BVET
Institut für Viruskrankheiten und Immunprophylaxe

Partenaires et organisations internationales (Anglais)

Coordinator: ID-Lelystad Instituut (NL)

Résumé des résultats (Abstract) (Anglais)

The high costs of an Classical Swine Fever (CSF) -outbreak, the social impact and resistance against destruction of pigs have led to reconsideration of emergency vaccination against CSF. The application of marker vaccines that can provide early protection might contribute to improved intervention and control strategies and might limit the duration and costs of an outbreak.

The objective of this project is to understand the immune mechanisms underlying protection against CSF, in particular the mechanisms involved in early protection against clinical signs of CSF and in the reduction of (horizontal) virus transmission.
The knowledge about relevant viral components, and about the quality of the vaccine-induce immune response may contribute to the future development of new and safe marker vaccines that can induce a fast protective immune response.

Références bases de données (Anglais)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 00.0635